The Action of the Notch Locus in DROSOPHILA MELANOGASTER. II. Biochemical Effects of Recessive Lethals on Mitochondrial Enzymes

AUTOR(ES)

Thörig, George E. W.

RESUMO

We show that six mapped recessive lethal point mutations of the Notch locus affect mitochondrial enzyme activities: NADH oxidase, NADH dehydrogenase, succinate dehydrogenase and α-glycerophosphate dehydrogenase. The mutant N264-40, which has the same morphological and embryological effects as the Notch8 deletion, demonstrates the same biochemical effects and dosage relations as Notch8. The other five mapped recessive lethals also affect four enzymic activities. They show specific patterns of activity that depend in several cases on the wild-type chromosome in the heterozygous females. That effect occurs with mutants located in the extreme right part of the Notch locus where some mutations, according to other authors, show temperature-sensitive expression.

Documentos Relacionados

• The Effect of Radiation on Small Competing Populations of DROSOPHILA MELANOGASTER II. the Changing Frequencies of Autosomal Recessive Lethals
• Naturally Occurring Enzyme Activity Variation in DROSOPHILA MELANOGASTER. II. Relationships among Enzymes
• Interchromosomal Effects on Crossing over in Drosophila Melanogaster. II. a Reexamination of X Chromosome Inversion Effects
• Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster.
• Fitness Effects of Ems-Induced Mutations on the X Chromosome of DROSOPHILA MELANOGASTER. II. Hemizygous Fitness Effects