The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells.
AUTOR(ES)
Moore, M A
RESUMO
All mRNAs encoded by the adenovirus major late transcription unit share a common 5' noncoding region, 200 nucleotides in length, termed the tripartite leader sequence. To assess function of the tripartite leader, recombinant viruses were prepared which carried either a bona fide herpes simplex virus thymidine kinase gene or a modified thymidine kinase gene whose normal 5' noncoding domain was replaced with the adenovirus leader sequence. The tripartite leader simultaneously decreased the nuclear half-life and increased the cytoplasmic half-life of the thymidine kinase-specific mRNA. The tripartite leader stabilized the non-adenovirus mRNA only within the environment of an adenovirus-infected cell during the late phase of the infectious cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=338213Documentos Relacionados
- The Tripartite Leader Sequence of Subgroup C Adenovirus Major Late mRNAs Can Increase the Efficiency of mRNA Export
- Adenovirus proteins associated with mRNA and hnRNA in infected HeLa cells.
- mRNA from the transforming segment of the adenovirus 2 genome in productively infected and transformed cells.
- In vitro translation of adenovirus type 12-specific mRNA isolated from infected and transformed cells.
- Transcription of the genome of adenovirus type 12. I. Viral mRNA in abortively infected and transformed cells.