The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER.

AUTOR(ES)

Cousin, X

RESUMO

ESTHER (for esterases, alpha/betahydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases, lipases and hormone-sensitive lipases) sharing a similar structure of a central beta-sheet surrounded by alpha-helices. Among these proteins a wide range of functions can be found (hydrolases, adhesion molecules, hormone precursors). The purpose of ESTHER is to help comparison of structures and functions of members of the family. Since the last release, new features have been added to the server. A BLAST comparison tool allows sequence homology searches within the database sequences. New sections are available: kinetics and inhibitors of cholinesterases, fasciculin-acetylcholinesterase interaction and a gene structure review. The mutation analysis compilation has been improved with three-dimensional images. A mailing list has been created.

Documentos Relacionados

• aCHEdb: the database system for ESTHER, the alpha/beta fold family of proteins and the Cholinesterase gene server.
• The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates
• Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex.
• ESTHER, the database of the α/β-hydrolase fold superfamily of proteins
• Simulations of the folding pathway of triose phosphate isomerase-type alpha/beta barrel proteins.