The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
AUTOR(ES)
Giaccia, Amato J.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=517513Documentos Relacionados
- Gangliosides in Neurological and Neuromuscular Function, Development, and Repair
- Recent advancements in corpus luteum development, function, maintenance and regression: Forum introduction
- Response of tumour cells to hypoxia: role of p53 and NFkB.
- Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia: INACTIVATION OF RIBONUCLEOTIDE REDUCTASE AND REDOX-MEDIATED CHECKPOINT CONTROL*
- Essential Role for Mitochondrial Thioredoxin Reductase in Hematopoiesis, Heart Development, and Heart Function