The Carboxy Terminus of Simian Virus 40 Large T Antigen Is Required To Disrupt the Yeast Cell Cycle
AUTOR(ES)
Fewell, Sheara W.
FONTE
American Society for Microbiology
RESUMO
Wild-type and J domain mutant simian virus 40 large T antigens alter the cell cycle and bud morphology of Saccharomyces cerevisiae. In contrast, yeast cells expressing mutant T antigen lacking the carboxy-terminal 150 aa exhibit normal morphology, indicating that this region of T antigen is required for cell cycle disruption.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=155092Documentos Relacionados
- Monoclonal antibodies specific for the carboxy terminus of simian virus 40 large T antigen.
- Less than 40% of the simian virus 40 large T-antigen-coding sequence is required for transformation.
- The Molecular Chaperone Activity of Simian Virus 40 Large T Antigen Is Required To Disrupt Rb-E2F Family Complexes by an ATP-Dependent Mechanism
- Two separable functional domains of simian virus 40 large T antigen: carboxyl-terminal region of simian virus 40 large T antigen is required for efficient capsid protein synthesis.
- The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins