The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain.

AUTOR(ES)

Markham, P N

RESUMO

Rhodamine and tetraphenylphosphonium, the substrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr through direct interaction with its transcriptional activator BmrR. Here we show that the C-terminal domain of BmrR, expressed individually, binds both these compounds and therefore can be used as a model for molecular analysis of the phenomenon of multidrug recognition.

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