The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster.
AUTOR(ES)
Lamb, R G
RESUMO
The effect of acute and chronic ethanol intake on hepatic glycerolipid biosynthesis in the hamster was studied by in vivo and in vitro techniques. The results were compared with those from control hamsters receiving isocaloric amounts of glucose. Both chronic and acute ethanol intake elevated serum and hepatic triglyceride concentrations and induced a rapid rise in the capacity of neutral glycerolipid formation from sn[1,3-14C]glycerol-3-phosphate by hamster liver homogenate and microsomal fractions. Ethanol intake also produced a corresponding increase in the incorporation of [1,3-14C]glycerol into hepatic neutral glycerolipids by the intact animal. The ethanol-induced rise in the capacity of neutral glycerolipid production by liver as measured in vivo and in vitro correlated well with an increase in hepatic phosphatidate phosphohydrolase activity. Therefore, the rise in hepatic and serum triglyceride levels associated with ethanol intake may be explained in part by an increase in the activity of the enzyme.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=371912Documentos Relacionados
- Effect of chronic endogenous hypergastrinaemia on pancreatic growth and carcinogenesis in the hamster.
- Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster.
- Effects of chronic ethanol intake on mobilization and excretion of cholesterol in baboons.
- Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.
- Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.