The Effect of Marker Heterozygosity on the Power to Detect Linkage Disequilibrium

AUTOR(ES)

Ott, J.

RESUMO

The relationship between marker heterozygosity and the power to detect linkage disequilibrium is examined through the analysis of an example and through a simulation study. The analysis suggests that, despite the penalties for multiple testing incurred with multiple alleles, greater heterozygosity results in greater power. The results of the simulation study are in accord with those of the analysis.

Documentos Relacionados

• The Power to Detect Linkage Disequilibrium with Quantitative Traits in Selected Samples
• Effect of Mating Structure on Variation in Linkage Disequilibrium
• The Effect of Combining Alleles into Electrophoretic Classes on Detecting Linkage Disequilibrium
• The Lowdown on Linkage Disequilibrium
• The Effect That Genotyping Errors Have on the Robustness of Common Linkage-Disequilibrium Measures