The Embryonically Active Gene, Unkempt, of Drosophila Encodes a Cys(3)his Finger Protein
AUTOR(ES)
Mohler, J.
RESUMO
The unkempt gene of Drosophila encodes a set of embryonic RNAs, which are abundant during early stages of embryogenesis and are present ubiquitously in most somatic tissues from the syncytial embryo through stage 15 of embryogenesis. Expression of unkempt RNAs becomes restricted predominantly to the central nervous system in stages 16 and early 17. Analysis of cDNAs from this locus reveals the presence of five Cys(3)His fingers in the protein product. Isolation and analysis of mutations affecting the unkempt gene, including complete deletions of this gene, indicate that there is no zygotic requirement for unkempt during embryogenesis, presumably due to the contribution of maternally supplied RNA, although the gene is essential during post-embryonic development.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1205012Documentos Relacionados
- The Drosophila neuralized gene encodes a C3HC4 zinc finger.
- The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development.
- Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation.
- Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration.
- The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.