The Interactions of Three Widely Separated Loci Controlling Conversion Properties of w Locus I in ASCOBOLUS IMMERSUS
AUTOR(ES)
Helmi, Shaker
RESUMO
Gene conversion properties of white (w) ascospore locus I in the Pasadena strains of Ascobolus immersus are controlled by complex interactions between three separate conversion control factors ( ccfs), which can give conversion frequencies at wI ranging from less than 1% up to 33%. ccf-2, which has three alleles, is very closely linked to wI but does not usually co-convert with it. ccf-2(K) and ccf-2(91) give lower conversion frequencies than ccf-2(P) and are incompletely dominant to ccf-2(P), with cis/trans position effects on conversion of wI. The "super" factor ( Helmi and Lamb 1979) has two interacting but unlinked components, ccf-3E and ccf-4r, which approximately double the conversion frequency at wI. ccf-2 (linkage group VIII), ccf-3 (linkage group I) and ccf-4 are probably all unlinked but interact and specifically control conversion at wI. ccf-3E could code for a diffusible product that affects the action of different ccf-2 alleles, which probably act by controlling the frequency of initiation of hybrid-DNA, which spreads into the adjacent wI locus. ccf-4R could code for a diffusible inhibitor of ccf-3E product, or be an alternative binding site for ccf-3E product. The dominance of ccf-4R depends on which ccf-2 alleles are present in the cross.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1202067Documentos Relacionados
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