The Macrophage-Induced Gene mig as a Marker for Clinical Pathogenicity and In Vitro Virulence of Mycobacterium avium Complex Strains

AUTOR(ES)

Meyer, Martin

FONTE

American Society for Microbiology

RESUMO

The capacity of 20 Mycobacterium avium complex isolates to multiply intracellularly in human monocyte-derived macrophages was assessed and correlated to the clinical relevance of each isolate and its reactivity with several candidate genetic virulence markers. The strongest correlation with a virulence phenotype was found for a conserved coding sequence of the macrophage-induced gene mig identified by a specific mig restriction fragment length polymorphism type.

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