The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections.
AUTOR(ES)
Martinez, J
RESUMO
Antibodies against the major cysteine proteinase (cruzipain) from Trypanosoma cruzi were detected in human sera obtained from patients with chronic Chagas' disease. Not only the intact 60-kDa enzyme but also its 25-kDa self-proteolysis fragment are antigenic in vivo. Although T. cruzi antigens 13 and 36 also reacted with the apparently monospecific antiproteinase serum, the antigenicity of cruzipain to human patients is genuine, since its reactivity was not modified by the adsorption of human sera with the recombinant proteins 13 and 36.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=259030Documentos Relacionados
- Suppression of cellular responses in mice during Trypanosoma cruzi infections.
- Cruzipain Induces Both Mucosal and Systemic Protection against Trypanosoma cruzi in Mice
- A New Cruzipain-Mediated Pathway of Human Cell Invasion by Trypanosoma cruzi Requires Trypomastigote Membranes
- Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi.
- Multiple gonococcal pilin antigenic variants are produced during experimental human infections.