The miaA Mutator Phenotype of Escherichia coli K-12 Requires Recombination Functions

AUTOR(ES)

Zhao, Jingyong

FONTE

American Society for Microbiology

RESUMO

miaA mutants, which contain A-37 instead of the ms2i6A-37 hypermodification in their tRNA, show a moderate mutator phenotype leading to increased GC→TA transversion. We show that the miaA mutator phenotype is dependent on recombination functions similar to, but not exactly the same as, those required for translation stress-induced mutagenesis.

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