The Parasitophorous Vacuole Membrane of Encephalitozoon cuniculi Lacks Host Cell Membrane Proteins Immediately after Invasion

AUTOR(ES)

Fasshauer, Verena

FONTE

American Society for Microbiology

RESUMO

Microsporidia of the genus Encephalitozoon develop inside a parasitophorous vacuole (PV) of unknown origin. Using colocalization studies, the PV was found to be absent from the endocytic pathway markers early endosomal autoantigen 1, transferrin receptor, and lysosome-associated membrane protein 1 and for the endoplasmic reticulum marker calnexin. The nonfusiogenic characteristic of the PV appears to be acquired as early as 1 min postinfection and is not reversed by drug treatment with albendazole or fumagillin.

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