THE PATHOGENESIS OF AUTOIMMUNITY IN NEW ZEALAND MICE, I. INDUCTION OF ANTINUCLEIC ACID ANTIBODIES BY POLYINOSINIC·POLYCYTIDYLIC ACID

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RESUMO

Antibodies to DNA and RNA were induced in young NZB/NZW F1 (B/W) female mice following multiple injections of the interferon-inducer polyinosinic·polycytidylic acid (poly I·poly C). Despite serum concentrations of interferon adequate to inhibit the C-type murine leukemia viruses, there was an acceleration of the autoimmune disease in these animals. Anti-RNA, but not anti-DNA antibodies, were induced in B/W male mice, as well as in NZB and NZW mice. Anti-RNA antibodies were also found in 50 per cent of female B/W mice who had never received poly I·poly C and in 8 of 24 sera from patients with systemic lupus erythematosus.

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