The Pharmacological Activity of Extracts of Cotton Dust
AUTOR(ES)
Davenport, Anne
RESUMO
Aqueous extracts prepared from dust collected in the card-rooms of several cotton mills have been prepared and found to contain activity which contracts the smooth muscle of guinea-pig ileum, guinea-pig trachea, rat stomach strip, and rat duodenum. The extracts contained an unknown contractor substance which was dialysable, resistant to boiling for one hour, and not destroyed by the action of proteolytic enzymes. They also contained a small amount of 5-hydroxytryptamine. One of the dust samples also contained histamine, but it could not be detected in the other samples, one of which was known to possess bronchoconstrictor properties in man. The particulate material, even after repeated washing, was found to have some stimulant action on guinea-pig ileum.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1038127Documentos Relacionados
- Some Pharmacological Actions of Cotton Dust and Other Vegetable Dusts
- Cotton Dust in Relation to Byssinosis: Part II: Skin Tests for Allergy with Extracts of Cotton Dust
- Biophysical alteration of lung surfactant by extracts of cotton dust.
- Histamine Liberation by Cotton Dust Extracts: Evidence Against its Causation by Bacterial Endotoxins
- Effects in man and rabbits of inhalation of cotton dust or extracts and purified endotoxins1
