The PickPocket method for predicting binding specificities for receptors based on receptor pocket similarities: application to MHC-peptide binding
AUTOR(ES)
Zhang, Hao
FONTE
Oxford University Press
RESUMO
Motivation: Receptor–ligand interactions play an important role in controlling many biological systems. One prominent example is the binding of peptides to the major histocompatibility complex (MHC) molecules controlling the onset of cellular immune responses. Thousands of MHC allelic versions exist, making determination of the binding specificity for each variant experimentally infeasible. Here, we present a method that can extrapolate from variants with known binding specificity to those where no experimental data are available.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2732311Documentos Relacionados
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