The relation between tonicity and impulse-evoked transmitter release in the frog

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RESUMO

1. The increase in miniature end-plate potential (m.e.p.p.) frequency in response to tetanic stimulation of the motor nerve at frog neuromuscular junctions in Ca2+-free, Mg2+ EGTA-containing (0 Ca2+—Mg2+ EGTA) solutions of varying tonicity has been studied. The response to stimulation is markedly increased in hypertonic solutions and is decreased in hypotonic solutions. Under these conditions changes in tonicity have comparable effects on stimulated and spontaneous quantal release.

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