The Requirement for Ribosomal Proteins L7 and L12 in Peptide-Chain Termination

AUTOR(ES)

Brot, Nathan

RESUMO

Proteins L7 and L12 from 50S ribosomal subunits of Escherichia coli are required for peptidechain termination. This termination process is inhibited by thiostrepton. Since both thiostrepton-treated ribosomes and those depleted of L7 and L12 have a markedly reduced ability to form release factor·UA[3H]A·ribosome complexes, the binding of release factors to the ribosome appears to be the primary site of inhibition.

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