The ring-type polymerase sliding clamp family
AUTOR(ES)
Bruck, Irina
FONTE
BioMed Central
RESUMO
Ring-type polymerases consist of a DNA polymerase, a ring-shaped sliding clamp protein and a clamp-loading complex. Sliding clamp proteins are found in all organisms and are called proliferating cell nuclear antigen (PCNA) in eukaryotes and the β clamp in prokaryotes. Both PCNA and β form a ring around DNA, which is made up of two subunits of three domains each in β but three subunits of two domains each in PCNA. Despite this difference and a lack of detectable sequence homology, the structures of the two rings are very similar. The sliding clamp slides along DNA and tethers the polymerase to the DNA, enabling rapid and processive DNA replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=150441Documentos Relacionados
- Functional Analysis of the RING-Type Ubiquitin Ligase Family of Arabidopsis1[w]
- The sliding clamp of DNA polymerase III holoenzyme encircles DNA.
- Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I
- The β subunit sliding DNA clamp is responsible for unassisted mutagenic translesion replication by DNA polymerase III holoenzyme
- Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer