The role of bisphosphonates in breast cancer: Direct effects of bisphosphonates on breast cancer cells
AUTOR(ES)
Senaratne, Siddhika G
FONTE
BioMed Central
RESUMO
In addition to inhibiting bone resorption, bisphosphonates have also been shown to exhibit antitumour effects. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in cultured human breast cancer cells. In addition, bisphosphonate treatment interferes with breast cancer cell adhesion to bone matrix, and inhibits cell migration and invasion. The combination of bisphosphonates with other anticancer drugs such as the taxoids markedly enhances these effects. These newly recognized direct actions of bisphosphonates on breast cancer cells indicate that these agents may have a greater role to play in treatment of patients suffering from cancers with a propensity to metastasize to bone.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138711Documentos Relacionados
- The role of bisphosphonates in breast cancer: Development of bisphosphonates
- The role of bisphosphonates in breast cancer: Actions of bisphosphonates in animal models of breast cancer
- The role of bisphosphonates in breast cancer: The present and future role of bisphosphonates in the management of patients with breast cancer
- Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention
- Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro.
