The role of pH, PCO2, and bicarbonate in regulating rat diaphragm citrate content

AUTOR(ES)
RESUMO

Intact rat diaphragms were exposed in vitro to varying CO2 tensions and bicarbonate concentrations, and the steady-state citrate content of diaphragm muscle was measured to investigate the relationship between metabolism and extracellular pH, PCO2, and (HCO3-). In addition, rat hemidiaphragms were incubated with 1,5-citrate-14C under different acid-base conditions, and 14CO2 production was determined as a measure of citrate oxidation.

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