THE ROLES OF SYNTHESIS AND DEGRADATION IN DETERMINING TISSUE CONCENTRATIONS OF LACTATE DEHYDROGENASE-5*

AUTOR(ES)

Fritz, Paul J.

RESUMO

C14-labeled amino acids were incorporated in vivo into LDH-5 of rat tissues. Different amounts of LDH-5 in liver, heart muscle, and skeletal muscle resulted from differences in rates of both intracellular degradation and synthesis. Rate constants for LDH-5 synthesis were 65, 2, and 5 picomoles per day per gram in rat liver, heart muscle, and skeletal muscle, respectively; rate constants for degradation were 0.041, 0.399, and 0.018 reciprocal days, respectively. The corresponding half-lives for LDH-5 in these tissues were 16, 1.6, and 31 days.

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