The Salmonella enterica Serovar Typhimurium Divalent Cation Transport Systems MntH and SitABCD Are Essential for Virulence in an Nramp1G169 Murine Typhoid Model
AUTOR(ES)
Zaharik, Michelle L.
FONTE
American Society for Microbiology
RESUMO
Nramp1 is a transporter that pumps divalent cations from the vacuoles of phagocytic cells and is associated with the innate resistance of mice to diverse intracellular pathogens. We demonstrate that sitA and mntH, genes encoding high-affinity metal ion uptake systems in Salmonella enterica serovar Typhimurium, are upregulated when Salmonella is internalized by Nramp1-expressing macrophages and play an essential role in systemic infection of congenic Nramp1-expressing mice.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=517450Documentos Relacionados
- Transcriptional Regulation of sitABCD of Salmonella enterica Serovar Typhimurium by MntR and Fur
- SitABCD Is the Alkaline Mn2+ Transporter of Salmonella enterica Serovar Typhimurium
- Regulation of Salmonella enterica Serovar Typhimurium mntH Transcription by H2O2, Fe2+, and Mn2+
- Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not Influence Salmonella-Induced Enteropathogenesis
- Respiratory Hydrogen Use by Salmonella enterica Serovar Typhimurium Is Essential for Virulence