The second century of the antibody. Molecular perspectives in regulation, pathophysiology, and therapeutic applications.

AUTOR(ES)

Braun, J

RESUMO

The modern age of immunology began in 1890 with the discovery of antibodies as a major component of protective immunity. The 2nd century of the antibody begins with a focus on the molecular physiology and pathophysiology of immunoglobulin production. Numerous human variable-region antibody genes have been identified through advances in molecular cloning and anti-variable-region monoclonal antibodies. Some of these variable-region genes are now known to be involved in specific stages of B-lymphocyte differentiation and immune development. This connection has yielded new insights into the pathogenesis of immune dyscrasias and lymphoid neoplasia; common variable immunodeficiency and cryoglobulinemia are highlighted here. The molecular regulation of immunoglobulin expression suggests new targets for pathogenesis and clinical intervention. Finally, genetically engineered antibodies offer novel opportunities for diagnostic and therapeutic applications.

Documentos Relacionados

• Pediatric Molecular Pathology: Quantitation and Applications. Perspectives in Pediatric Pathology
• The Leukemias. Etiology, Pathophysiology, and Treatment
• Gynecomastia: Pathophysiology, Evaluation, and Management
• Midwife regulation, education, and practice in The Netherlands during the nineteenth century.
• Advances in the Pathophysiology, Diagnosis, and Treatment of Sickle Cell Disease