The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression.
AUTOR(ES)
Koide, Y
RESUMO
We examined the signal transduction mechanism responsible for the gamma interferon-induced indoleamine 2,3-dioxygenase (IDO) gene expression in a human monocytic cell line, THP-1. Our results suggest that gamma interferon-induced activation of protein tyrosine kinase is a prerequisite for gene expression and that activation of protein kinase C and another unknown signal(s), both of which are transduced by the protein tyrosine kinase, synergistically induce IDO gene expression. Neither Ca2+ influx nor cyclic nucleotide-dependent kinases were suggested to be involved in the signaling pathway.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=186208Documentos Relacionados
- Nitric Oxide-Mediated Regulation of Gamma Interferon-Induced Bacteriostasis: Inhibition and Degradation of Human Indoleamine 2,3-Dioxygenase
- Inhibition of Chlamydia pneumoniae Replication in Human Aortic Smooth Muscle Cells by Gamma Interferon-Induced Indoleamine 2,3-Dioxygenase Activity
- Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.
- The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-α-induced depression
- A nuclear tyrosine phosphatase downregulates interferon-induced gene expression.