The stabilization and release of hirudin from liposomes or lipid-assemblies coated with hydrophobically modified dextran

AUTOR(ES)

Mumper, Russell J.

FONTE

Springer-Verlag

RESUMO

Hirudin is a 65-amino acid peptide and the most potent and specific known inhibitor of thrombin (Ki=0.2 pM). The short elimination half-life of hirudin from the body (1 hour) necessitates the use of a sustained and controlled delivery system.

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