The target of rapamycin (TOR) proteins

AUTOR(ES)

Raught, Brian

FONTE

The National Academy of Sciences

RESUMO

Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. The TOR proteins regulate (i) the initiation and elongation phases of translation, (ii) ribosome biosynthesis, (iii) amino acid import, (iv) the transcription of numerous enzymes involved in multiple metabolic pathways, and (v) autophagy. Intriguingly, recent studies have also suggested that TOR signaling plays a critical role in brain development, learning, and memory formation.

Documentos Relacionados

• A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)
• Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
• Regulation of RNA Polymerase III Transcription Involves SCH9-dependent and SCH9-independent Branches of the Target of Rapamycin (TOR) Pathway*
• Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene
• Regulation of cellular growth by the Drosophila target of rapamycin dTOR