The total synthesis of (–)-crispatene
AUTOR(ES)
Miller, Aubry K.
FONTE
National Academy of Sciences
RESUMO
The total synthesis of the molluscan polypropionate (–)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The absolute configuration of (–)-crispatene and related molecules is established.