The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis
AUTOR(ES)
Furley, Andrew J
FONTE
BioMed Central
RESUMO
A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138964Documentos Relacionados
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