The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response

AUTOR(ES)

Hartwig, Daiane D, Bacelo, Kátia L, Oliveira, Thaís L, Schuch, Rodrigo, Seixas, Fabiana K, Collares, Tiago, Rodrigues, Oscar, Hartleben, Cláudia P, Dellagostin, Odir A

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

23/01/2015

RESUMO

We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.

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