Theatre: a software tool for detailed comparative analysis and visualization of genomic sequence
AUTOR(ES)
Edwards, Yvonne J. K.
FONTE
Oxford University Press
RESUMO
Theatre is a web-based computing system designed for the comparative analysis of genomic sequences, especially with respect to motifs likely to be involved in the regulation of gene expression. Theatre is an interface to commonly used sequence analysis tools and biological sequence databases to determine or predict the positions of coding regions, repetitive sequences and transcription factor binding sites in families of DNA sequences. The information is displayed in a manner that can be easily understood and can reveal patterns that might not otherwise have been noticed. In addition to web-based output, Theatre can produce publication quality colour hardcopies showing predicted features in aligned genomic sequences. A case study using the p53 promoter region of four mammalian species and two fish species is described. Unlike the mammalian sequences the promoter regions in fish have not been previously predicted or characterized and we report the differences in the p53 promoter region of four mammals and that predicted for two fish species. Theatre can be accessed at http://www.hgmp.mrc.ac.uk/Registered/Webapp/theatre/.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=168908Documentos Relacionados
- SeeGH – A software tool for visualization of whole genome array comparative genomic hybridization data
- Illoura™: a software tool for analysis, visualization and semantic querying of cellular and other spatial biological data
- Alfresco—A Workbench for Comparative Genomic Sequence Analysis
- Teatro Campesino &Black Revolutionary Theatre: ruptura, inovação e transformação
- GATA: a graphic alignment tool for comparative sequence analysis