Thiolester Substrates for Transamidating Enzymes: Studies on Fibrinoligase

AUTOR(ES)

Lorand, L.

RESUMO

Esters of thiocholine were shown to inhibit the crosslinking of fibrin clots by the transamidating enzyme, fibrinoligase (thrombin-activated fibrin-stabilizing factor or activated Factor XIII). Inhibition depended on the nature of the acylating group with the phenylpropionyl, phenylbutyryl, and trans-cinnamoyl esters being most effective of the compounds tested so far.

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