Thymosin increases production of T-cell growth factor by normal human peripheral blood lymphocytes.
AUTOR(ES)
Zatz, M M
RESUMO
The in vitro incubation of phytohemagglutinin-stimulated peripheral blood lymphocytes with thymosin results in a marked and reproducible increase in production of T-cell growth factor, which is dose dependent and most pronounced in the first 24 hr of culture. Incubation of lymphocytes with thymosin alone failed to induce any production of T-cell growth factor. The biological activity of thymosin fraction 5 cannot be attributed to the activity of thymosin alpha 1, one of the well-characterized peptide components of fraction 5. These data provide the basis for (i) a potential mechanism for the in vivo immunorestorative effects of thymosin in primary and secondary immunodeficiencies and (ii) identification of an additional, but as yet undefined, immunoregulatory component of thymosin fraction 5.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345176Documentos Relacionados
- Human T-cell leukemia virus type II transforms normal human lymphocytes.
- T-cell receptor delta-chain diversity in peripheral lymphocytes.
- Human leukemia cell maturation induced by a T-cell lymphokine isolated from medium conditioned by normal lymphocytes.
- Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.
- T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.