Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae
AUTOR(ES)
Marinho, Márcia, Táparo, Cilene Vidovix, Oliveira Júnior, Itamar S., Perri, Silvia Helena Venturoli, Cardoso, Tereza Cristina
FONTE
J. Venom. Anim. Toxins incl. Trop. Dis
DATA DE PUBLICAÇÃO
11/08/2015
RESUMO
This investigation aimed to evaluate the occurrence of some apoptotic features induced by
The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed.
Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2,4 and 7 (p = 0.025; p <0.05). Lung sections revealed caspase-3 labeled alveolar cells in 10 and 14 days post-infection was higher than observed at 7 days (p = 0.0497; p < 0.05). Liver sections demonstrated reactive cells at a highest level at 14 and 21 days post-infection when comparison to 2,4, 7 and 10 days (p = 0.0069; p<0.05).
Our results suggest that infection of L
Documentos Relacionados
- Immune response to infection by Leptospira interrogans serovar icterohaemorrhagiae in genetically selected mice
- TNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola
- Efficacy of ciprofloxacin against Leptospira interrogans serogroup icterohaemorrhagiae.
- Prozone effects in microscopic agglutination tests for leptospirosis in the sera of mice infected with the pathogenic Leptospira interrogans serovar Canicola
- Susceptibility of mice treated with cyclophosphamide to lethal infection with Leptospira interrogans Serovar pomona.