TOTAL SYNTHESIS OF dl-19-NOR-16,17-DEHYDROPROGESTERONE
AUTOR(ES)
Daum, Sol J.
RESUMO
dl-2-(7,11-Dimethyl-3,7,11 - trans,trans-dodecatrienyl)-3-methyl-cyclopent-2-enol was prepared by reduction of the corresponding ketone. This tetraenol, on treatment with trifluoroacetic acid, underwent stereoselective cyclization to give dl-3,17-dimethyl-A-nor-D-homoestra-3,16-diene. This tetracyclic material was readily converted, by oxidative cleavage to the bicyclic triketo aldehyde followed by a double aldol cyclization, into dl-19-nor-16,17-dehydroprogesterone.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=277793Documentos Relacionados
- 16,17-Seco- and 2,3:16,17-di-Seco-pregnanes from Guarea guidonia
- Proceedings of the Physiological Society, 16-17 July 1982, Cambridge Meeting: Demonstrations
- Proceedings of the Physiological Society, 16-17 December 1988, Cardiff Meeting: Demonstrations
- Proceedings of the Physiological Society, 16-17 December 1988, Cardiff Meeting: Poster Communications
- A REVOLTA DE CORÉ, DATÃ E ABIRAM (NM 16-17): ANÁLISE ESTILÍSTICO-NARRATIVA E INTERPRETAÇÃO
