Toward an understanding of the folding of ribonuclease A.

AUTOR(ES)

Scheraga, H A

RESUMO

A mechanism was proposed several years ago for the regeneration of native ribonuclease A (EC 3.1.27.5) from the fully reduced form by a mixture of oxidized and reduced glutathiones. Several folding pathways, depending on the solution conditions, were deduced. It is shown here that recent criticisms of those results are due to a misinterpretation of the analysis of our data. A more detailed description of our method of analysis of our previous kinetic and energetic data is presented in order to clarify possible misconceptions.

Documentos Relacionados

• Early folding intermediate of ribonuclease A.
• Toward a better understanding of protein folding pathways.
• Toward an understanding of the structural basis of translation
• Toward an outline of the topography of a realistic protein-folding funnel.
• Toward an understanding of the molecular mechanisms of physiological cell death.