Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

AUTOR(ES)

Plumier, J.-C. L.

FONTE

Cell Stress Society International

RESUMO

Using transgenic mice constitutively expressing the human inducible Hsp70, we examined the role of Hsp70 on cell survival after focal cerebral oschemia. Twenty-four hours after premanent occlusion of the middle cerebral artery, no difference in infarct area was detected between Hsp70-transgenic and non-transgenic mice. In the non-transgenic mice, many pyramidal neurons of the ipsilateral hippocampus were observed to be pykontic. However, in all Hsp70-transgenic mice, hippocampal pyramidal neurons showed normal morphology and no evidence of pyknosis. This suggests that constitutive expression of Hsp70 reduces the extent of damage following permanent middle cerebral artery occlusion.

Documentos Relacionados

• Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
• Heat-inducible human factor that binds to a human hsp70 promoter.
• Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70.
• A hitchhiker's guide to the human Hsp70 family
• The inducible Hsp70 as a marker of tumor immunogenicity