Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.
AUTOR(ES)
Schuuring, E
RESUMO
In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362732Documentos Relacionados
- The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.
- Differential expression of jun and fos genes during differentiation of mouse P19 embryonal carcinoma cells.
- The int-1 proto-oncogene products are glycoproteins that appear to enter the secretory pathway.
- Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells.
- Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells.