Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume.
AUTOR(ES)
Holt, D E
RESUMO
The transplacental transfer of cefuroxime was determined at antenatal fetal blood sampling in a cross sectional study of 78 patients between 15-35 weeks' gestation, 8-138 minutes after a maternal intravenous dose of 750 mg. Mean serum cefuroxime concentration, measured by high performance liquid chromatography, was 7.4 (95% confidence interval (CI) 6.8 to 8.1) mg/l in control fetuses; concentrations in hydropic fetuses were similar (6.2 mg/l, CI 4.7 to 7.7) but in fetuses with oligohydramnios they were significantly lower, (4.9 mg/l, CI 3.6 to 6.2). Antibiotic concentration did not correlate with gestational age and remained unchanged by transfusion of packed red cells. We conclude that (i) fetal serum concentrations of cefuroxime obtained after a maternal dose of 750 mg are only adequate for prophylaxis against organisms with a minimum inhibitory concentration of < 4 mg/l and (ii) transplacental passage of cefuroxime is significantly reduced in the presence of oligohydramnios.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1029171Documentos Relacionados
- Concentration of fetal plasma and amniotic fluid interleukin-1 in pregnancies complicated by preterm prelabour amniorrhexis.
- Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume.
- Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study
- CLINICAL STUDIES OF THE BLOOD VOLUME. VII. CHANGES IN BLOOD VOLUME IN BRIGHT'S DISEASE WITH OR WITHOUT EDEMA, RENAL INSUFFICIENCY, OR CONGESTIVE HEART FAILURE, AND IN HYPERTENSION 1
- Changes in serum C-reactive protein during complicated and uncomplicated measles virus infections.
