Treatment of Meningitis Due to Methicillin-Resistant Staphylococcus epidermidis with Linezolid

AUTOR(ES)

Krueger, Wolfgang A.

FONTE

American Society for Microbiology

RESUMO

Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.

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