Triterpenes and antitubercular activity of Byrsonima crassa
AUTOR(ES)
Higuchi, Celio Takashi, Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Sannomiya, Miriam, Vilegas, Wagner, Leite, Sergio Roberto de Andrade, Sacramento, Luis Vitor S., Sato, Daisy Nakamura
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2008
RESUMO
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.
Documentos Relacionados
- Antioxidant activity of Byrsonima crassa Nied. and Byrsonima fagifolia Nied. in induced gastric lesions experimental models
- Preparation and antitubercular activity of lipophilic diamines and amino alcohols
- Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
- Design, Synthesis and Antitubercular Activity of Novel Isoniazid-Cyclic-Amine-Azachalcones Hybrids
- Design, Synthesis and Antitubercular Activity of 2-(Benzylthio)-1H-benzo[d]imidazoles