Trypanocidal and Leishmanicidal Properties of Substitution-Containing Chalcones
AUTOR(ES)
Lunardi, Fabiane
FONTE
American Society for Microbiology
RESUMO
Ten chalcones were synthesized and tested as potential leishmanicidal and trypanocidal agents. All tested compounds caused concentration-dependent inhibition of the in vitro growth of Leishmania braziliensis and Trypanosoma cruzi with no significant toxic effect towards host macrophages. Our results show that the positions of the substituents seem to be critical for their antiprotozoal activities.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=152493Documentos Relacionados
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