Tubular reabsorption of sodium during acute and chronic volume expansion in man

AUTOR(ES)

Alexander, Edward A.

RESUMO

Renal hemodynamics and tubular fractional sodium reabsorption (FSR) were evaluated by clearance techniques during acute and chronic extracellular volume expansion in man. (1 − V/GFR) × 100 was used as an index of proximal and (CH2O/V) × 100 as an estimate of distal fractional reabsorption. After acute loading with isotonic saline 37 ml/kg body wt, proximal FSR decreased by 4.8% and distal FSR decreased by 4.4%. After comparable chronic expansion by mineralocorticoids (“escape”), proximal FSR also decreased by 3.9%, but distal reabsorption was not altered.

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