Two Mutations in the First Gene of the Histidine Operon of Salmonella typhimurium Affecting Control
AUTOR(ES)
Rothman-Denes, Lucia
RESUMO
Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=248666Documentos Relacionados
- Cloning and restriction map of the first part of the histidine operon of Salmonella typhimurium.
- Construction of φ80 dhis Carrying Salmonella typhimurium Histidine Operon Mutations1
- Transcription Initiation in the Histidine Operon of Salmonella typhimurium*
- Histidine Regulation in Salmonella typhimurium VIII. Mutations of the hisT Gene
- Histidyl-Transfer Ribonucleic Acid Synthetase in Positive Control of the Histidine Operon in Salmonella typhimurium1