Two non-allelic human interferon alpha genes with identical coding regions.

AUTOR(ES)

Todokoro, K

RESUMO

A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.

Documentos Relacionados

• Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice.
• Multiple non-allelic genes encoding pancreatic alpha-amylase of mouse are expressed in a strain-specific fashion.
• The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes.
• Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.
• Analysis of 21 Stargardt's disease families confirms a major locus on chromosome 1p with evidence for non-allelic heterogeneity in a minority of cases.