Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni)
AUTOR(ES)
Thornhill, Joyce, Kusel, John, Oliviera, Fabricia Alvisi de, Ribeiro, Fabio, Lima, Symone Fulgêncio, Coelho, Paulo Marcos Zech, McVeigh, Paul, Mattos, Ana Carolina Alves
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2010-07
RESUMO
Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and then diffuse throughout the body of the parasite. We present a hypothesis that the internal cells of the body of the schistosomulum represent a new host-parasite interface, at which skin-derived growth factors may stimulate receptors on internal membranes during transformation of the cercariae into the schistosomulum.
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