Use of microspheres of poly (L-lactide acid) contends medication in the treatment of loss of the tissue dental / Utilização de microesferas de poli (L-acido-latico) contendo medicamento no tratamento de perda do tecido dental

AUTOR(ES)
DATA DE PUBLICAÇÃO

2004

RESUMO

One of the points that it should be considered of difficult solution in Brazil, is the loss dentine. Several materials have been studied to minimize the problem, but none assists to the needs of such application. In that sense, the objective of the present to evaluate the biocompatibility of the Poly (L-lactide acid), PLLA, contends vancomicina and piroxicam in the treatment of great dentin losses where cannot or not to happen the exhibition of the dental pulp, cases where the exhibition takes to the treatment endodontic or exodontia. For so much, studies in was accomplished In vivo in rabbits and humans, both approved by the Comitê de Ética em Pesquisa da Universidade Estadual de Campinas to seem number 490/2003. The studies in rabbits were accomplished being used of an experimental model where it was implanted the microesferas contends medication in the incisive central and after 20, 40, and 60 days the teeth were cut and submitted to the analysis histological. After 20 days of it implants, it was verified central areas of hipocalcification in relation to the it implants and formation of dentin points. Inflammatory process was not located in function of the use of the medications. After 40 days the one was verified that the calcification begins for areas interglobules that grow and they are founded, even so the process a lot of times it is imperfect, not resulting areas of organic matrix not calcified; they are the areas interglobules. After 60 days, the formation of normality tissue was verified that demonstrates the effectiveness of the microspheres with medication as reparative material. The analysis in vivo in humans if made necessary to evaluate the answer front to the application of the material, its effect antiinflammatory and analgesic in cases of exhibition pulp and great loss dentine, besides the evaluation of the return of the function to the dental element, that is to say, control ofthe pain and possibility of normal mastication. It was observed after 60 days that ali the implanted patients didn t present pain to none of the accomplished tests and they maintained the vitality pulpar, the microspheres with medication here was shown also effective in the control antiinflammatory and infectious. The study in vivo it indicated that the microspheres of PLLA contends vancomicina and piroxicam they present great potential for they be used for application in subject, since the material favors the formation of a neodentine and it controls the inflammatory and infectious processes

ASSUNTO(S)

dental pulp meriais dentarios polimeros controlled release technology dentine dental materials polpa dentaria tecnologia de liberação controlada polymers dentina

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