v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
AUTOR(ES)
Langdon, W Y
RESUMO
Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=286647Documentos Relacionados
- Identification of two murine loci homologous to the v-cbl oncogene.
- A model for spontaneous B-lineage lymphomas in IgHμ-HOX11 transgenic mice
- The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.
- Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.
- Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome.