Vaccine-Induced Protection against Helicobacter pylori in Mice Lacking Both Antibodies and Interleukin-4
AUTOR(ES)
Garhart, Christine A.
FONTE
American Society for Microbiology
RESUMO
To test the hypothesis that a Th2 response to Helicobacter pylori is necessary for protection and to address the possibility that humoral and Th2 cellular responses may compensate for each other, we generated mice deficient in both interleukin-4 (IL-4) and antibodies. The immunized double-knockout mice were protected from H. pylori challenge, as were the parental strains and wild-type C57BL/6 mice. Neutralization of IL-4 in B-cell-deficient mice did not prevent protection. Immunized IL-5-deficient mice were also protected. Thus, IL-4 and IL-5 are not essential for protection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=155749Documentos Relacionados
- Role of Signal Sequence in Vaccine-Induced Protection against Experimental Coccidioidomycosis
- Vaccine-Induced Reduction of Helicobacter pylori Colonization in Mice Is Interleukin-12 Dependent but Gamma Interferon and Inducible Nitric Oxide Synthase Independent
- Vaccine-induced immunity against cutaneous leishmaniasis in BALB/c mice.
- Fluorescent-Antibody Marker for Vaccine-Induced Rubella Antibodies
- Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1.
